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曹眾雙聘教授

電子郵箱：caozhong@mail.sysu.edu.cn

博士生導師，中山大學中法核工程與技術學院和中山大學生物醫學工程學院雙聘教授

一、教育與研究經歷

2024.4-至今，中山大學，生物醫學工程，教授/博導

2016.7-2024.3，中山大學，生物醫學工程，副教授/博導

2011.2-2016.6，中山大學，生物醫學工程，講師

2007.9-2011.1，哈爾濱工業大學，生物醫學工程，博士

2005.9-2007.7，哈爾濱工業大學，無機化學，碩士

2001.9-2005.7，哈爾濱師范大學，化學，學士

二、學科方向

生物材料方向，研究方向是醫學成像引導的腫瘤治療（醫學成像包括磁共振、超聲、光聲成像等）、靶向藥物輸送、醫學影像探針和多功能診療納米藥物等。

（1）醫學影像探針用于腫瘤、炎癥等疾病的影像可視化治療

開發新型磁共振、超聲、CT和多模態診療探針，將兩種或多種成像模式相互融合，深入到細胞和分子水平的成像以獲取疾病組織更深層次及更精確的生物學信息，同時進行協同治療并能探索疾病分子水平上的變化，進一步提高疾病的治療效果。

（2）靶向藥物輸送平臺

設計和開發新型納米載藥系統，如高分子納米粒子、脂質體、外泌體和微泡等，用以包埋/攜載酶、小分子肽、藥物和DNA等。重點設計可以通過外源性（光、超聲）或內源性（腫瘤微環境）響應來控制釋放速度的新型藥物載體系統。

三、主持科研項目

1、國家自然科學基金委員會, 面上項目（52073313）, 2021-01-01 至 2024-12-31

2、國家自然科學基金委員會, 重點項目, 51933011, 2020-01-01 至 2024-12-31, 300萬元, 項目骨干

3、國家自然科學基金青年基金（81101142），2012/01-2014/12

4、廣東省基礎與應用基礎研究基金自然科學基金面上項目（2414050004370）， 2024年01月01~2026年12月31日

5、廣東省自然科學基金-面上項目（2018A0303130273），2019/1-2021/12

6、廣東特支計劃“科技創新青年拔尖人才”（2015TQ01R510），2016/1-2018/12

7、廣東省自然科學基金-面上項目（2016A030313324），2016/3-2019/3

8.深圳市高等院校穩定支持計劃（2023A002），2023/10/01-2026/9/30

9. 廣州市科技計劃項目（201707010308），2017/1-2019/12

10. 廣東省自然科學基金博士啟動項目（S2011040005922），2011/10-2013/10

四、論文、專利和專著

SCI論文（第一或通訊作者）

[1].Xiaotong Liang?, Wenbo Chen, Chunan Wang, Kai Jiang, Jinjin Zhu, Ruitao Lu, Zhousheng Lin, Zhong Cao*, Jian Zheng*, A Mesoporous Theranostic Platform for Ultrasound and Photoacoustic Dual Imaging-guided Photothermal and Enhanced Starvation Therapy for Cancer. Acta Biomaterialia, 2024，DOI:10.1016/j.actbio.2024.05.040 (SCI, IF=9.7)

[2].Chunlei Dai, Liying Wang, Xinru You, Yi Zhao, Zhong Cao*, Jun Wu*, Coffee-derived self-anti-in?ammatory polymer as drug nanocarrier for enhanced rheumatoid arthritis treatment. Chinese Chemical Letters, 2024, DOI: 10.1016/j.cclet.2024.109869 (SCI, IF=9.1)

[3].Fan Zhang, Liwen Feng, Changchang Jia, Yingjian Wu, Jie Liu, Xintao Shuai*, Zhong Cao*，Mixed-valence Pt(0)/Pt2+ nanoassemblies as high-Z radiosensitizers and metallo-immune regulators for potent radiotherapy of breast cancer, Nano Today,2023, 48: 101708 (SCI, IF=17.4)

[4].Sitong Liu#, Chen Zhang#, Yuanyuan Zhou#, Fang Zhang, Xiaohui Duan, Yang Liu, Xibang Zhao, Jie Liu, Xintao Shuai, Jiali Wang*, Zhong Cao*, MRI-visible mesoporous polydopamine nanoparticles with enhanced antioxidant capacity for osteoarthritis therapy, Biomaterials, 2023, 295:17. (SCI, IF=14.0)

[5].Xiuqi Hou#, Xi Yang#, Yanwen Xu, Jiayin Lin, Fang Zhang, Xiaohui Duan, Sitong Liu, Jie Liu, Jun Shen, Xintao Shuai*, Zhong Cao*, Manganese-doped mesoporous polydopamine nanoagent for T1–T2 magnetic resonance imaging and tumor therapy. Nano Research, 2023, 16(2): 2991(SCI, IF=9.9)

[6].Ruling Zhang#, Meng Liu#, Sitong Liu, Xiaotong Liang, Ruitao Lu, Xintao Shuai3*, Dalin Wu*, Zhong Cao* ,Holmium (III)-Doped Multifunctional Nanotheranostic Agent for Ultra-High-Field Magnetic Resonance Imaging-Guided Chemo-Photothermal Tumor Therapy，Acta Biomaterialia, 2023,172, 454-465. (SCI, IF=9.7)

[7].Shuyan Han, Peikun Xin, Qilun Guo, Zhong Cao,* Hai Huang,* and Jun Wu*. Oral Delivery of Protein Drugs via Lysine Polymer-Based Nanoparticle Platform.Advanced Healthcare Materials, 2023, 14, 2300311 (SCI, IF=10.0)

[8].Xiaoge Zhang, Xiaomei Chen, Peng Zhang, Meiting Li, Miao Feng, Yaqian Zhang, Lili Cheng, Junjie Tang, Langtao Xu, Yadong Liu, Zhuoyin Liu, Zhong Cao*, Jie Liu*. Nano Research（1998-0124）, 2022, 16(5):7148-7163 (SCI, IF=9.9)

[9].Xin Meng, Fan Zhang, Huanling Guo, Chunyang Zhang, Hangtong Hu, Wei Wang, Jie Liu, Xintao Shuai, Zhong Cao*. Advanced Healthcare Materials(2192-2640), 2021,10(19):2100780. (SCI, IF=10.0)

[10].Qingqing Guan#, Ruomi Guo#, Shihui Huang, Fan Zhang, Jie Liu, Zhiyong Wang, Xi Yang, Xintao Shuai*, Zhong Cao*. Mesoporous polydopamine carrying sorafenib and SPIO nanoparticles for MRI-guided ferroptosis cancer therapy. Journal of Controlled Release, 2020, 320: 392. (SCI, IF=10.8)

[11].Dan Wu#, Xiaohui Duan#, Qingqing Guan, Jie Liu, Xi Yang, Fang Zhang, Peng Huang, Jun Shen,* Xintao Shuai,* Zhong Cao*. Mesoporous polydopamine carrying manganese carbonyl responds to tumor microenvironment for multimodal imaging-guided cancer therapy. Advanced Functional Materials. 2019, 29(16):1900095. (SCI, IF=19.0)

[12].Chunyang Zhang, Jie Liu, Huanling Guo, Wei Wang, Ming Xu, Yang Tan, Tongyi Huang, Zhong Cao,* Xintao Shuai,* and Xiaoyan Xie*.Theranostic Nanomedicine Carrying L-Menthol and Near-Infrared Dye for Multimodal Imaging-Guided Photothermal Therapy of Cancer. Advanced Healthcare Materials（2192-2640）, 2019, 8(16):1900409. (SCI, IF=10.0)

[13]. Chunyang Zhang#, Dan Wu#, Liejing Lu, Xiaohui Duan, Jie Liu, Xiaoyan Xie, Xintao Shuai, Jun Shen, Zhong Cao*. Multifunctional Hybrid Liposome as a Theranostic Platform for Magnetic Resonance Imaging Guided Photothermal Therapy. ACS Biomaterials Science & Engineering, 2018, 4(7), 2597-2605. (SCI, IF=5.7)

[14].Chunyang Zhang, Zhu Wang, Chunan Wang, Xiongjun Li, Jie Liu, Ming Xu, Xiaoyan Xie, Qing Jiang, Wei Wang*, Zhong Cao*. Highly Uniform Per?uoropropane-Loaded Cerasomal Microbubbles as a Novel Ultrasound Contrast Agent. ACS applied materials & interface. 2016, 8(24):15024-15032. (SCI, IF=9.5)

[15].Zhong Cao*, Wenjian Zhu, Wei Wang, Chunyang Zhang, Ming Xu, Jie Liu, Shiting Feng, Qing Jiang, Xiaoyan Xie. Stable cerasomes for simultaneous drug delivery and magnetic resonance imaging. International Journal of Nanomedicine. 2014, 9:5103-5116. (SCI, IF=8.0)

[16].Chun-yang Zhang, Zhong Cao*, Wenjian Zhu, Jie Liu, Qing Jiang and Xintao Shuai. Highly uniform and stable cerasomal microcapsule with good biocompatibility for drug delivery. Colloids and Surfaces B: Biointerfaces. 2014, 116:327-333. (SCI, IF=5.8)

[17].Zhong Cao*, Wenjian Zhu, Wei Wang, Chunyang Zhang, Ming Xu, Jie Liu, Shiting Feng, Qing Jiang, Xiaoyan Xie*. Stable cerasomes for simultaneous drug delivery and magnetic resonance imaging. International Journal of Nanomedicine. 2014, 9:5103-5116. (SCI, IF=8.0)

[18].Zhong Cao, Xiuli Yue, Zhifei Dai*. Modulation of Release of Paclitaxel from Composite Cerasomes. Colloids and surfaces B: Biointerfaces, 2012, 98:97-104. (SCI, IF=5.8)

[19]. Zhong Cao, Yan Ma, Xiuli Yue, Shouzhu Li, Zhifei Dai*. Stabilized liposomal hybrid cerasomes for drug delviery applications. Chemical Communications. 2010, 46(29):5265~5267. (SCI, IF=4.9)

授權發明專利

[1].曹眾，管青青，武丹，一種介孔聚多巴胺負載羰基錳的多功能納米診療劑及其制備方法與應用，授權國家發明專利，2021-06-05, ZL 201810204475.0

[2].曹眾，朱瑾瑾，一種介孔聚多巴胺包載液態氟碳類超聲造影劑及其制備方法，授權國家發明專利，2021-05-04, ZL 201811032467.4，

[3].曹眾，吳英健，楊茜，一種用于腫瘤T1-T2磁共振成像的介孔聚多巴胺納米粒，2022-5，授權國家發明專利，ZL 202110157804.2

[4].曹眾，管青青，郭宇，郭若汨，一種靶向介孔聚多巴胺多功能納米診療劑及其制備方法與應用，2022-02-01，授權國家發明專利，ZL 201811091438.X

[5].曹眾，丁夢麗，一種聚多巴胺納米診療劑及其制備方法，2021-06-25，授權國家發明專利， ZL 201811023981.6，

[6].曹眾，王春安，蔣慶. 一種集超聲造影與熱療為一體的診療制劑的制備方法, 2019-02-05, 授權國家發明專利，ZL 201610246252.1

[7].曹眾，李佳. 羅新，楊斌健，陳薇玲. 一種載藥硅脂質超聲造影劑的制備方法和應用，2018-4-20，授權國家發明專利，ZL 201510161089.4

[8].曹眾，朱文健，蔣慶.一種熱增強型有機-無機復合脂質納米液態氟碳類超聲造影劑及其制備方法，2014.11.5，中國，ZL201310413651.9

[9].曹眾，張春陽，蔣慶，一種硅質體微膠囊及其制備方法,2014.8.13，中國，ZL201210407792.5

[10].曹眾，張春陽，蔣慶. 一種抗癌藥物硅質體微膠囊及其制備方法，2014.6.11，中國，ZL201210407849.1

[11].曹眾，張春陽，蔣慶.一種紫杉醇硅質體微膠囊的制備方法，2015.7.22，中國，ZL201310542881.5